EXPRESSION INHIBITOR OF NF-&kgr;B RELA GENE, PHARMACEUTICALS FOR ALLERGIC DERMATITIS AND APPLICATIONS THEREOF

摘要

PROBLEM TO BE SOLVED: To provide a novel expression inhibitor capable of efficiently inhibiting expression of NF-κB RelA gene, and to provide pharmaceuticals for allergic dermatitis.SOLUTION: An expression inhibitor of RelA gene comprises a single stranded nucleic acid molecule comprising 5' region (Xc), inner region (Z) and 3' region (Yc) in this order from 5' to 3', where the inner region (Z) comprises inner 5' region (X) and inner 3' region (Y) linked together, the 5' region (Xc) is complementary to the inner 5' region (X), the 3' region (Yc) is complementary to the inner 3' region (Y), and the inner region (Z) comprises an expression inhibiting sequence that inhibits the expression of NF-κB gene. Preferably, the expression inhibitor further comprises a functional peptide Cys-His-His-Arg-Arg-Arg-Arg-His-His-Cys, of which N terminal is stearylated.