发明名称 |
HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF CYSTIC FIBROSIS |
摘要 |
<p>The present invention provides pyridin-oxadiazole/thiadiazole derivatives of Formula I wherein A is N or CR 4a; and (ii) or (iii) which restore or enhance the function of mutant and/or wild type CFTR to treat cystic fibrosis, primary ciliary dyskinesia, chronic bronchitis, chronic obstructive pulmonary disease, asthma, respiratory tract infections, lung carcinoma, xerostomia and keratoconjunctivitis sire, or constipation (IBS, IBD, opioid induced). Pharmaceutical compositions comprising such derivatives are also encompassed.</p> |
申请公布号 |
EP2755967(B1) |
申请公布日期 |
2015.10.21 |
申请号 |
EP20120783308 |
申请日期 |
2012.09.14 |
申请人 |
NOVARTIS AG |
发明人 |
BALA, KAMLESH, JAGDIS;BUTLER, REBECCA;COLLINGWOOD, STEPHEN, PAUL;HALL, EDWARD, CHARLES;EDWARDS, LEE;LEGRAND, DARREN, MARK;SPIEGEL, KATRIN |
分类号 |
C07D413/04;A61K31/4439;A61K31/497;A61K45/06;A61P11/00;C07D417/04 |
主分类号 |
C07D413/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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