Neural stimulation devices and systems for treatment of chronic inflammation

摘要

A system for treating chronic inflammation may include an implantable microstimulator, a wearable charger, and optionally an external controller. The implantable microstimulator may be implemented as a leadless neurostimulator implantable in communication with a cervical region of a vagus nerve. The microstimulator can address several types of stimulation including regular dose delivery. The wearable charger may be worn around the subject's neck to rapidly (<10 minutes per week) charge an implanted microstimulator. The external controller may be configured as a prescription pad that controls the dosing and activity of the microstimulator.

主权项

1. A leadless, implantable microstimulator device for treating chronic inflammation, the device comprising:
a hermetically sealed capsule body; at least two electrically conductive capsule regions, wherein each region electrically connects to an electrode for applying stimulation to a vagus nerve; a resonator within the sealed capsule body, the resonator comprising a coil and a capacitor configured to resonate at a predetermined frequency range; a thermistor positioned to monitor the temperature of the coil; a battery within the sealed capsule body; and an electronic assembly within the sealed capsule body; wherein the electronic assembly comprises power management circuitry configured to receive power from the resonator to charge the battery, a microcontroller configured to control stimulation of the vagus nerve from the conductive capsule regions, and an overtemperature control configured to detune the resonator to reduce energy absorption when the thermistor measures a temperature exceeding a predetermined threshold temperature.