发明名称 |
método para diagnóstico de cânceres que expressam o receptor de her2 ou suas variantes truncadas |
摘要 |
The present invention relates to a method of diagnosis and therapy of cancers expressing the HER2 receptor. The invention provides antibodies or fragments thereof that recognizes an epitope of a HER2 receptor truncated form, said epitope being defined by a sequence included in SEQ ID NO: 2. The invention also provides a method of cancer diagnosis, which comprises the detection of the presence of the HER2 receptor truncated form consisting of the amino acid sequence SEQ ID NO: 1 in a patient sample. |
申请公布号 |
BRPI0914969(A2) |
申请公布日期 |
2015.10.20 |
申请号 |
BR2009PI14969 |
申请日期 |
2009.06.05 |
申请人 |
FUNDACIÓ PRIVADA INSTITUCIÓ CATALANA DE RECERCA IESTUDIS AVANCATS;FUNDACIÓ PRIVADA INSTITUT D'INVESTIGACIÓ ONCOLÓGICA DE VALL HEBRON;FUNDACIÓ PRIVADA INSTITUT DE RECERCA HOSPITAL UNIVERSITARI VALL HEBRON |
发明人 |
JOAQUÍN ARRIBAS LÓPEZ;JOSEP LLUIS PARRA PALAU;JOSÉ BASELGA TORRES;KIM PEDERSEN;PIER-DAVIDE ANGELLINI;SIRLE LAOS |
分类号 |
A61K47/48;C07K16/22;C07K16/30 |
主分类号 |
A61K47/48 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|