Wettable silicone hydrogel contact lenses

摘要

Silicone hydrogel contact lenses are formed from the reaction product of a polymerizable composition comprising at least one acrylate-containing siloxane monomer, at least one hydrophilic vinyl-containing monomer, and at least one vinyl-containing cross-linking agent, wherein the polymerizable composition has a molar ratio of total amount of hydrophilic vinyl-containing monomer to total amount of acrylate-containing siloxane monomer of from 5:1 to 30:1, respectively. The silicone hydrogel contact lenses have good manufacturing processability, can be manufactured without the use of alcohol solvents, and have excellent surface wettability.

主权项

1. A silicone hydrogel contact lens comprising:
a polymeric lens body that is the reaction product of a polymerizable composition comprising: a) at least one mono-functional acrylate-containing siloxane monomer having a molecular weight of less than 1000; b) at least one bi-functional acrylate-containing siloxane monomer represented by formula (II),  wherein R1 of formula (II) is selected from either hydrogen or a methyl group, R2 of formula (II) is selected from either hydrogen or a C1-4 hydrocarbon group, m of formula (II) represents an integer of from 0 to 10; n of formula (II) represents an integer of from 4 to 100, and a and b represent integers of 1 or more; c) at least one hydrophilic vinyl-containing monomer; and d) at least one vinyl-containing cross-linking agent, wherein the polymerizable composition has a molar ratio of total amount of hydrophilic vinyl-containing monomer to total amount of acrylate-containing siloxane monomer of from 5:1 to 30:1, respectively and wherein the polymerizable composition has a molar ratio of total amount of polymerizable vinyl groups from the total amount of hydrophilic vinyl-containing monomer to total amount of polymerizable vinyl groups from the total amount of vinyl-containing cross-linking agents of from 100:1 to 1000:1, respectively.