Multimeric peptide conjugates and uses thereof

摘要

The present invention relates to multimeric (e.g., dimeric, trimeric) forms of peptide vectors that are capable of crossing the blood-brain barrier (BBB) or efficiently entering particular cell types. These multimeric peptide vectors, when conjugated to agents (e.g., therapeutic agents) are capable of transporting the agents across the BBB or into particular cell types. These compounds are therefore particularly useful in the treatment of neurological diseases.

主权项

1. A compound having a structure comprising the formula:
A1-X1-A2 wherein A1 is a peptide vector comprising the amino acid sequence of SEQ ID NO:114; A2 is a peptide vector comprising the amino acid sequence of SEQ ID NO:97; and X1 is a linker comprising a carbon-sulfur bond formed by reaction of a maleimido group of the linker and the sulfhydryl group of the Cys at position 20 of SEQ ID NO:114 of A1.