发明名称 Crystalline forms of an antiviral benzimidazole compound
摘要 The invention relates to crystalline forms of 5,6-dichloro-2-(isopropylamino)-1-β-L-ribofuranosyl-1H-benzimidazole, pharmaceutical compositions comprising the same, processes for preparing the same, and their use in medical therapy.
申请公布号 US9163052(B2) 申请公布日期 2015.10.20
申请号 US201113012924 申请日期 2011.01.25
申请人 GlaxoSmithKline LLC 发明人 Glover Bobby Neal;Huang Lian-Feng;Lancaster Robert William;Long Stacey Todd;Rizzolio Michele Catherine;Schmitt Eric Allen;Sickles Barry Riddle
分类号 A01N43/04;A61K31/70;C07H19/00;C07H19/04;C07H19/052;A61K31/4184;C07D405/04 主分类号 A01N43/04
代理机构 代理人 Thomas Robert Steve
主权项 1. A pharmaceutical composition comprising a crystalline form of Form I 5,6-dichloro-2-(isopropylamino)-1-β-L-ribofuranosyl-1Hbenzimidazole having substantially the same X-ray powder diffraction pattern as FIG. 1, wherein said X-ray diffraction pattern is obtained with a diffractometer equipped with a diffracted beam curved graphite monochromator and utilizing copper Kα X-radiation, and at least one pharmaceutically acceptable carrier therefor; with the proviso that the pharmaceutical composition is not a solution of the active ingredient.
地址 Wilmington DE US