Pharmaceutical formulations based on apolar and polar lipids for ophthalmic use

摘要

The present invention refers to pharmaceutical formulations based on lipids for ophthalmic use comprising a phospholipid component composed of zwitterionic phospholipids of natural origin and an oily component composed of oils of natural origin emulsified in water. In particular, the invention refers to ophthalmic formulations useful, for example, for transporting drugs to the eye and in the treatment of ocular dryness, capable of restoring the lipid layer of the tear film. In particular, in a non-transitory but pathological situation such as the dry eye syndrome, such formulations also succeed in reducing the often-present inflammatory component.

主权项

1. A pharmaceutical composition for ophthalmic use, said composition comprising
a phospholipid component composed of zwitterionic egg yolk phospholipids and an oily component consisting of one or more oils of essentially natural origin, and free of any synthetic oil or mineral oil, wherein the weight ratio of the oily component to the phospholipid component is in the range of 4:1 to 1:1, the phospholipid component is present from 0.1%-5% by weight, and the oily component is present from 0.3%-15% by weight, and a buffer with low ionic force in an amount sufficient to maintain the pH of the finished product in the range of 6.5-8, said buffer being selected from the group consisting of histidine and Tris and combinations thereof, to maintain stability of the composition.