Antibodies against the ectodomain of ErbB3 and uses thereof
摘要
<p>The present invention provides a novel class of antibodies and antigen binding fragments thereof that bind the extracellular domain of ErbB3 receptor and inhibit various ErbB3 functions. For example, the antibodies and antigen binding fragments described herein are capable of binding to the receptor designated ErbB3 and inhibiting EGF-like ligand mediated phosphorylation of the receptor. Such antibodies and antigen binding fragments thereof have the useful characteristic of inhibiting the proliferation of cancer cells expressing ErbB3.</p>
申请公布号
AU2010284018(C1)
申请公布日期
2015.10.15
申请号
AU20100284018
申请日期
2010.08.23
申请人
MERRIMACK PHARMACEUTICALS, INC.
发明人
SCHOEBERL, BIRGIT;NIELSEN, ULRIK;FELDHAUS, MICHAEL