发明名称 |
Compositions and methods for bacterial delivery of polypeptides |
摘要 |
The methods and compositions described herein relate to the delivery of polypeptides to a target cell, e.g. by utilizing engineered non-pathogenic bacteria comprising a type three secretion system (T3SS) and T3SS-compatible substrates. In one aspect, described herein are non-pathogenic microbial cells that have been engineered to express both a functional type three secretion system (T3SS) and at least one polypeptide that is compatible with the T3SS. Due to the wide variety of polypeptides that can be delivered to a target eukaryotic cell using the compositions and systems described herein, a commensurately wide variety of applications is contemplated, e.g. therapeutics and reprogramming. |
申请公布号 |
AU2014225717(A1) |
申请公布日期 |
2015.10.15 |
申请号 |
AU20140225717 |
申请日期 |
2014.03.06 |
申请人 |
PRESIDENT AND FELLOWS OF HARVARD COLLEGE;THE GENERAL HOSPITAL CORPORATION |
发明人 |
LESSER, CAMMIE;WAGERS, AMY;REEVES, ANALISE Z. |
分类号 |
A61K35/74 |
主分类号 |
A61K35/74 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|