METHOD OF DETERMINING CANCER PROGNOSIS

摘要

Provided is a method of predicting the prognosis of a patient with ovarian cancer by determining the total number of somatic exome mutations per genome (Nmut) and status of the BRCA1 and/or BRCA2 in the subject.

主权项

1. A method for determining the prognosis of a subject with ovarian cancer, the method comprising
obtaining a cell sample from the subject; determining the number of mutations in the exons of the tumor sample to determine a tumor mutation burden in the cell sample; and determining whether the BRCA1 gene or BRCA2 gene is mutant or wild-type in the cells to determine a BRCA1 and BRCA2 status for the subject, wherein a high tumor mutation burden and a mutation in either a BRCA1 gene or BRCA2 gene indicates the subject has a better prognosis than a subject with a low tumor mutation burden.