Anti-GCC antibody molecules

摘要

Antibodies and antigen-binding fragments of antibodies that bind GCC are disclosed. In some embodiments, the antibodies are humanized, chimeric or human. Nucleic acids and vectors encoding the antibodies or portions thereof, recombinant cells that contain the nucleic acids, and compositions comprising the antibodies or antigen-binding fragments are also disclosed. The invention also provides therapeutic and diagnostic methods utilizing the antibodies and antigen-binding.

主权项

1. An anti-GCC antibody molecule comprising one or more light chain variable region and/or heavy chain variable regions selected from the group consisting of:
a) MS7 heavy chain variable region Amino Acid Sequence SEQ ID NO:1; and/or MS7 light chain variable region Amino Acid Sequence SEQ ID NO:2; and b) MS20 heavy chain variable region Amino Acid Sequence SEQ ID NO:3; and/or MS20 light chain variable region Amino Acid Sequence SEQ ID NO:4;wherein the anti-GCC antibody molecule is
i) an antibody that binds to human guanylyl cyclase C that is selected from the group consisting of: a monoclonal antibody and a chimeric antibody; or ii) an antigen-binding fragment of an antibody that binds to human guanylyl cyclase C that is selected from the group consisting of: a Fab fragment, Fab′ fragment, F(ab′)2 fragment, an scFv fragment, a double chain antigen-binding fragment, an Fd fragment, a dAb fragment; a single chain antibody, a functional heavy chain antibody and a diabody.