| 发明名称 |
COMPOSITIONS AND METHODS FOR TREATING PROTEINOPATHIES |
| 摘要 |
This disclosure relates to methods for improving neural function in a mammal with a proteinopathy comprising administering a therapeutically effective amount of an agent that increases glucocerebrosidase activity in the mammal. Also disclosed are methods for reducing toxic lipids, reducing α-synuclein, and/or inhibiting the accumulation of protein aggregates in a mammal with a proteinopathy comprising administering a therapeutically effective amount of an agent that increases glucocerebrosidase activity. |
| 申请公布号 |
US2015284472(A1) |
申请公布日期 |
2015.10.08 |
| 申请号 |
US201314440818 |
申请日期 |
2013.11.04 |
| 申请人 |
GENZYME CORPORATION |
发明人 |
Sardi Sergio Pablo;Shihabuddin Lamya;Cheng Seng |
| 分类号 |
C07K16/40;A61K38/47;A61K35/76;A61K9/00 |
主分类号 |
C07K16/40 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for improving neural function in a mammal with a proteinopathy comprising administering a therapeutically effective amount of an agent that increases glucocerebrosidase activity in the mammal. |
| 地址 |
Cambridge MA US |
