发明名称 |
E-CONFIGURATION BENZAMIDE COMPOUND AND PHARMACEUTICAL FORMULATION AND APPLICATION THEREOF |
摘要 |
Disclosed are an E-configuration benzamide compound and pharmaceutical formulation and application thereof. The E-configuration benzamide compound has a structure represented by formula (I), with the chemical name of N-(2-amino-4-fluorophenyl)-4-[N-[(E)-3-(3-pyridine) acryl] aminomethyl] benzamide, and 3-pyridine acryl in the structural formula having E-configuration. The E-configuration benzamide compound represented by formula (I) has subtype selective histone deacetylated enzyme inhibitory activity, mainly inhibiting HDAC1, HDAC2, HDAC3 in type I HADC and HDAC10 in type IIb HDAC. The E-configuration benzamide compound represented by formula (I) can be used to treat diseases related to abnormal activity of the histone deacetylated enzyme, such as cancer, including lymphoma, solid tumor and blood system tumor and the like. |
申请公布号 |
WO2015149435(A1) |
申请公布日期 |
2015.10.08 |
申请号 |
WO2014CN80585 |
申请日期 |
2014.06.24 |
申请人 |
SHENZHEN CHIPSCREEN BIOSCIENCES, LTD. |
发明人 |
LU, XIANPING;LI, ZHIBIN;XU, XUEKUI |
分类号 |
C07D213/56;A61K9/14;A61K9/20;A61K31/4406;A61P35/00;A61P35/02 |
主分类号 |
C07D213/56 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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