| 主权项 |
1. A compound comprising a structure of Structure X:including crystals, stereoisomers, pharmaceutically acceptable solvates, and pharmaceutically acceptable salts thereof, further including mixtures thereof in all ratios, wherein:
each RA1-RA4 are independently selected from the group consisting of H, F, Cl, Br, and I; X2 is selected from the group consisting of —C(═O)—NH— and —NH—C(═O)—; L1 is —(CH2)n—, wherein n is 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10, and any one or more of the —CH2— may be replaced by a group selected from the group consisting of aryl, heteroaryl, cycloalkyl, heterocycloalkyl, substituted aryl, substituted heteroaryl, substituted cycloalkyl, substituted heterocycloalkyl, —O—, —S—, —C(═O)—, —S(═O)—, —S(═O)2—, —NH—C(═O)—, —C(═O)—NH—, —NR—, —C═C—, and —C≡C—; X1 is selected from the group consisting of —C(═O)—NH—, —NH—C(═O)—, and —NH—; Y1 is selected from the group consisting of H, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, substituted aryl, substituted heteroaryl, substituted cycloalkyl, substituted heterocycloalkyl, —OH, —SH, and —NH2; Y2 is —(CH2)p—, wherein p is 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10, and any one or more of the —CH2— may be replaced by a group selected from the group consisting of alkyl, —C═C—, —C≡C—, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, substituted aryl, substituted heteroaryl, substituted cycloalkyl, substituted heterocycloalkyl, —O—, —S—, —N—, —C(═O)—, and —C(═S)—; X is S, P or C, wherein: when X is S, and m is 2, Rx is selected from the group consisting of H, alkyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, substituted alkyl, substituted aryl, substituted heteroaryl, substituted cycloalkyl, and substituted heterocycloalkyl; and Ry is nothing; when X is P, and m is 1, Rx and Ry are independently selected from the group consisting of H, alkyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, substituted alkyl, substituted aryl, substituted heteroaryl, substituted cycloalkyl, and substituted heterocycloalkyl; when X is C, and m is 0, Rx is H, and Ry is and when X is C, and m is 1, Rx is nothing, and Ry is alkyl, alkyl carboxyl, whereinR1 selected from the group consisting of H,alkyl, and alkyl further substituted with aryl, heteroaryl, amino, hydroxide, hydroxide aryl, hydroxide carbonyl, amino carbonyl, thiol, alkyl-S—, or guanidinyl; and
R3 is alkyl. |
