| 主权项 |
1. A compound of formula (I)or a pharmaceutically acceptable salt thereof, wherein
p is 1 or 2; is a single or double bond; m is 0, 1, or 2; R1 is selected fromwherein R1 is attached to the parent molecular moiety through any substitutable carbon atom in the group;
n is 0, 1, 2, 3, 4, 5, or 6; o is 0, 1, 2, 3, 4, or 5; q is 0, 1, 2, 3, or 4; X0 is selected from CH and N; X1 is selected from CH and N; X2 and X3 are independently selected from CH, C(Ra) and N; provided that at least one of X1, X2, and X3 is other than N; X4 is selected from CH and CRa; one of X5, X6, X7, and X8 is N and the others are selected from CH and CRa; X9 is selected from CRa, CH, and N; each Ra is independently selected from alkenyloxy, alkoxy, alkoxyalkoxy, alkoxycarbonyl, alkyl, benzodioxanyl, carboxamido, carboxy, carboxyalkoxy, cyano, cycloalkyl, cycloalkylalkoxy, cycloalkyloxy, deuteroalkoxy, dialkylamino, halo, haloalkyl, haloalkoxy, haloalkoxycarbonyl, hydroxy, imidazolyl, morpholinyl, oxazolyl, phenyl, piperazinyl, pyrazolyl, pyridinyl, pyrrolidinyl, thiazolyl, and —NRqRq′, wherein the imidazolyl, the morpholinyl, the oxazolyl, the phenyl, the piperazinyl, the pyridinyl, the pyrrolidinyl, and the thiazolyl are optionally substituted with one or two groups independently selected from alkoxy, alkyl, alkylsulfonyl, halo, haloalkoxy, haloalkyl, and morpholinyl; and wherein two adjacent Ra groups, together with the carbon atoms to which they are attached, can optionally form a ring selected from dioxanyl, dioxolanyl, furanyl, morpholinyl, pyranyl, and phenyl, wherein the ring is optionally substituted with one or two groups independently selected from alkyl and halo; Rb is alkyl; Rx is selected from methyl and ethyl; Rz and Rz′ are independently selected from hydrogen and hydroxy; provided that when is a double bond, Rz and Rz′ are each hydrogen; R2 is selected from hydrogen, alkyl, deuteroalkyl, halo, haloalkoxy, haloalkyl, and hydroxyalkyl; R3 is selected from hydrogen, alkoxyalkoxycarbonyl, alkoxycarbonyl, alkylaminocarbonyl, alkylcarbonyl, cycloalkylalkoxycarbonyl, cycloalkylcarbonyl, cycloalkyloxycarbonyl, deuteroalkoxycarbonyl, deuterohaloalkoxycarbonyl, dialkylaminocarbonyl, dialkylaminocarbonylcarbonyl, haloalkoxycarbonyl, haloalkylaminocarbonyl, haloalkylcarbonyl, heterocyclylcarbonyl, heterocyclyloxycarbonyl, phenylcarbonyl, and phenyloxycarbonyl, wherein the cycloalkyl part of the cycloalkylalkoxycarbonyl, the cycloalkylcarbonyl, and the cycloalkyloxycarbonyl, the heterocyclyl part of the heterocyclylcarbonyl and the heterocyclyloxycarbonyl, and the phenyl part of the phenylcarbonyl and the phenyloxycarbonyl, is optionally substituted with one, two, or three groups independently selected from alkyl, alkylamino, alkylcarbonyl, cycloalkyl, dialkylamino, halo, haloalkoxy, and haloalkyl; one of Rq and Rq′ is selected from hydrogen and alkyl and the other is selected from alkylcarbonyl and phenylcarbonyl; and one of Y and Y′ is oxygen and the other is CH2. |
