Compounds, compositions and methods

摘要

Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.

主权项

1. A method of increasing cardiac contractility of cardiac tissue without changing the calcium transient comprising contacting the cardiac tissue with methyl-4-(2-fluoro-3-(6-methylpyridin-3-yl)benzyl)piperazine-1-carboxylate having the structure:or a pharmaceutically acceptable salt thereof.