Compositions and methods for the treatment of traumatic brain injury

摘要

Compositions and methods for the inhibition and/or prevention of traumatic brain injury and the symptoms associated with it are provided.

主权项

1. A method for reducing in a subject the pathology associated with traumatic injury to the brain, wherein said subject has sustained a traumatic brain injury, said method comprising administering to the subject at least one polymer and at least one pharmaceutically acceptable carrier,
wherein said polymer comprises at least one anti-inflammatory agent conjugated to the polymer, wherein said polymer is a N-(2-hydroxypropyl) methacrylamide (HPMA) copolymer having the structure:wherein m and n are independently from about 1 to about 1000, wherein R is a linker, and wherein said linker is an alkyl having one to about 15 carbons or a peptide having 1 to about 10 amino acids.