| 摘要 |
<p>A crystalline substance of Cefditoren pivoxyl, namely 7-[(Z)-2(2-aminothiazol-4-yl)-2-methoxyiminoacetamido]-3-[(Z)-2- (4-methylthiazol-5-yl)ethenyl]-3-cephem-4-carboxylic acid pivaloyloxymethyl ester is of orthorhombic form and has a melting point with decomposition at a temperature in a range of 206.2 - 215.7 °C as evaluated from the peak of thermal absorption shown in the heat flow curve of said substance determined by a differential scanning calorimeter, that a single crystal of said crystalline substance has a density of 1.21 to 1.23 g/cm3 and contains 4 molecules of Cefditoren pivoxyl within a unit lattice of the single crystal, that said crystalline substance has a purity of 97 % to 98 % for the Cefditoren pivoxyl component as measured by a liquid chromatography with using a reverse phase silica gel column and by detecting with ultra-violet ray absorption, and that said crystalline substance has a higher stability than the known amorphous substance of Cefditoren pivoxyl. It is described a process for the preparation of a crystalline substance of Cefditoren pivoxyl.</p> |
