| 摘要 |
Improved screen filter modules, related compartmentalized filtration modules, and related filtration processes, suitable for filtering fluid to eliminate suspended particulate matter, such as living cells or microcarriers anchoring living cells, or to separate particulate matter based on size. The improvement is the presence of a barrier that channels redirected filtrate to the portion of the filter most susceptible to clogging by the particulate matter and induces flow patterns that act against clogging. |
| 主权项 |
1. A screen filter module enhanced with an external barrier, the module comprising:
a) a retentate chamber, said chamber comprising a chamber wall and a chamber entrance, said chamber entrance permitting fluid containing suspended particulate matter to enter or exit the chamber, and wherein the chamber wall comprises a filter screen, said screen comprising pores, such that said screen permits fluid and particles smaller than the pores but not suspended particulate matter larger than the pores to flow through it; b) a barrier, said barrier positioned exterior to the retentate chamber so as to redirect fluid moving through the filter screen area proximal to the chamber entrance so that the redirected fluid moves towards a filter screen area more distal to the chamber entrance; c) an exiting space between the filter screen and the barrier, said space for permitting fluid flow; d) an opening between the filter screen and the perimeter of the barrier, said opening providing a means for fluid to leave the exiting space and escape the module; and e) an upper adapter for attachment to the filter screen, said adapter also attached to a rigid portion of the screen filter module, so as to prevent collapse of the filter screen. |
