PHARMACEUTICALLY ACTIVE COMPOSITIONS COMPRISING OXIDATIVE STRESS MODULATORS (OSM), NEW CHEMICAL ENTITIES, COMPOSITIONS AND USES

摘要

PROBLEM TO BE SOLVED: To provide compositions and methods for treating or inhibiting the occurrence, recurrence, of a disease, inflammation, degeneration, necrosis, hyperplasia or neoplasia (including infectious or non-infectious or progressive disease or metastatic progression or metastasis), a cancer or a disease precursor thereof.SOLUTION: This invention relates to a compound, which is a combination of an anti-oxidant and compounds capable of undergoing oxidation, for example, inhibitors of HDAC, Histone deacetylase or other anti-cancer drugs like doxorubicin or etoposide or other drugs, to a mammal diagnosed as having an inflammation, hyperplasia, neoplasia, disease or precursor disorder thereof, in an amount effective to treat or inhibit the occurrence, recurrence, progression of the inflammation, enlargement, hyperplasia, neoplasia, disease or precursor thereof.