| 发明名称 |
RECOMBINANT BISPECIFIC ANTIBODY BINDING TO CD20 AND CD95 |
| 摘要 |
A bispecific antibody format, which comprises a) a Fab fragment comprising a first binding site for a first antigen; b) an scFv fragment comprising a second binding site for a second antigen; and c) a CH2 domain, wherein the Fab fragment and the scFv fragment are linked via the CH2 domain, wherein the first antigen is CD95 and the second antigen is CD20; or the first antigen is CD20 and the second antigen is CD95. |
| 申请公布号 |
US2015274833(A1) |
申请公布日期 |
2015.10.01 |
| 申请号 |
US201314443752 |
申请日期 |
2013.11.19 |
| 申请人 |
BALIOPHARM AG |
发明人 |
Herrmann Andreas;Grosse-Hovest Ludger |
| 分类号 |
C07K16/28 |
主分类号 |
C07K16/28 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A bispecific antibody format, which comprises
a) a Fab fragment comprising a first binding site for a first antigen; b) an scFv fragment comprising a second binding site for a second antigen; and c) a CH2 domain, wherein the Fab fragment and the scFv fragment are linked via the CH2 domain, wherein the first antigen is CD95 and the second antigen is CD20; or the first antigen is CD20 and the second antigen is CD95. |
| 地址 |
Basel CH |
