| 发明名称 |
Antibodies that Bind and Block Triggering Receptor Expressed on Myeloid Cells-1 (TREM-1) |
| 摘要 |
The invention relates to antibodies that are capable of specifically binding TREM-1 and preventing the activation of TREM-1, a protein expressed on monocytes, macrophages and neutrophils. Such antibodies find utility in the treatment of individuals with an inflammatory disease, such as rheumatoid arthritis and inflammatory bowel disease. |
| 申请公布号 |
US2015274825(A1) |
申请公布日期 |
2015.10.01 |
| 申请号 |
US201514632079 |
申请日期 |
2015.02.26 |
| 申请人 |
Novo Nordisk A/S |
发明人 |
Stennicke Vibeke Westphal;Read Christine Brender;Grell Susanne Nedergaard;Wiberg Charlotte;Salbo Rune;Henriksen Anette;Padkjaer Soeren |
| 分类号 |
C07K16/28 |
主分类号 |
C07K16/28 |
| 代理机构 |
|
代理人 |
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| 主权项 |
1. An antibody or fragment thereof that is capable of specifically binding to and blocking TREM-1. |
| 地址 |
Bagsvaerd DK |
