| 主权项 |
1. A compound of formula (I)and/or a salt thereof,
wherein: G is a group of formula X is chosen from the group consisting of halogen, —CN, —C(═O)R28, —C(═O)OR28, —C(═O)NR24R28, —C(═O)C(═O)R28, —NR24R28, —NR24NR24R28, —N═NR28, —NR24OR28, —NR24C(═O)R28, —NR24C(═O)C(═O)R28, —NR24C(═O)OR28, —NR24C(═O)C(═O)OR28, —NR24C(═O)NR24R28, —NR24C(═O)NR24C(═O)R28, —NR24C(═O)NR24C(═O)OR28, —NR24C(═O)C(═O)NR24R28, —NR24S(═O)2R28, —NR24S(═O)2NR24R28, —OR28, —OC(═O)R28, —OC(═O)NR24R28, —OC(═O)OR28, —OS(═O)R28, —OS(═O)2R28, —OS(═O)2OR28, —OS(═O)2NR24R28, —S(═O)—R28, —S(═O)2NR24R28, and —S(═O)NR24R28; or X is chosen from the group consisting of C1-10alkyl, C2-6alkenyl, C2-6alkynyl, C6-11-aryl, C7-16arylalkyl, C3-11cycloalkyl, C4-17cycloalkylalkyl, 3-15 membered heterocycloalkyl, 4-21 membered heterocycloalkylalkyl, 5-15 membered heteroaryl, and 6-21 membered heteroarylalkyl wherein each of the foregoing are optionally substituted by 1-10 R19, R1 is chosen from the group consisting of C3-11cycloalkyl optionally substituted with 1-10 R19, C1-6-haloalkyl, and —OC1-6alkyl; R2, R3, R4, R5, are each independently selected from the group consisting of H, halogen, —CN, —C(═O)R20, —C(═O)OR20, —C(═O)NR22R23, —C(═O)C(═O)R20, —C(═NR25)R20, —C(═NR25)NR22R23, —C(═NOH)NR22R23, —C(═NOR26)R20, —C(═NNR22R23)R20, —C(═NNR24C(═O)R21)R20, —C(═NNR24C(═O)OR21)R20, —C(═S)NR22R23, —NC, —NO2, —NR22R23, —NR24NR22R23, —N═NR24, —NR24OR26, —NR24C(═O)R20, —NR24C(═O)C(═O)R20, —NR24C(═O)OR21, —NR24C(═O)C(═O)OR21, —NR24C(═O)NR22R23, —NR24C(═O)NR24C(═O)R20, —NR24C(═O)NR24C(═O)OR20, —NR24C(═NR25)NR22R23, —NR24C(═O)C(═O)NR22R23, —NR24C(═S)R20, —NR24C(═S)OR20, —NR24C(═S)NR22R23, —NR24S(═O)2R21, —NR24S(═O)2NR22R23, —NR24P(═O)R38R38, —NR24P(═O)(NR22R23)(NR22R23), —NR24P(═O)(OR20)(OR20), —NR24P(═O)(SR20)(SR20), —OR20, —OCN, —OC(═O)R20, —OC(═O)NR22R23, —OC(═O)OR20, —OC(═NR25)NR22R23, —OS(═O)R20, —OS(═O)2R20, —OS(═O)2OR20, —OS(═O)2NR22R23, —OP(═O)R38R38, —OP(═O)(NR22R23)(NR22R23), —OP(═O)(OR20)(OR20), —OP(═O)(SR20)(SR20), —Si(R24)3, —SCN, —S(═O)nR20, —S(═O)2OR20, —SO3R27, —S(═O)2NR22R23, —S(═O)NR22R23, —SP(═O)R38R38, —SP(═O)(NR22R23)(NR22R23), —SP(═O)(OR20)(OR20), —SP(═O)(SR20)(SR20), —P(═O)R38R38, —P(═O)(NR22R23)(NR22R23), —P(═O)(OR20)(OR20), and —P(═O)(SR20)(SR20); or R2, R3, R4, R5, are each independently selected from the group consisting of C1-6-alkyl, C2-6alkenyl, C2-6alkynyl, C6-11aryl, C7-16arylalkyl, C3-11cycloalkyl, C4-17-cycloalkylalkyl, 3-15 membered heterocycloalkyl, 4-21 membered heterocycloalkylalkyl, 5-15 membered heteroaryl, and 6-21 membered heteroarylalkyl wherein each of the foregoing groups may be optionally substituted with 1-10 R19, or any of R2 and R3 or R4 and R5 can, together with the atoms to which they are attached, form a C6-11aryl, C3-11cycloalkyl, 3-15 membered heterocycloalkyl or a 5-15 membered heteroaryl wherein each of the foregoing groups may be optionally substituted by 1-10 R19; R19 at each occurrence is independently chosen from the group consisting of Ci—6 alkyl optionally substituted by 1-13 R39, C2-6alkenyl optionally substituted by 1-11 R39, C2-6alkynyl optionally substituted by 1-9 R39, C6-11aryl optionally substituted by 1-11 R39, C7-16arylalkyl optionally substituted by 1-19 R39, C3-11cycloalkyl optionally substituted by 1-21 R39, C4-17cycloalkylalkyl optionally substituted by 1-32 R39, 3-15 membered heterocycloalkyl optionally substituted by 1-28 R39, 4-21 membered heterocycloalkylalkyl optionally substituted by 1-40 R39, 5-15 membered heteroaryl optionally substituted by 1-15 R39, 6-21 membered heteroarylalkyl optionally substituted by 1-27 R39, halogen, —CN, —C(═O)R30, —C(═O)OR30, —C(═O)NR32R33, —C(═O)C(═O)R30, —C(═NR35)R30, —C(═NR35)NR32R33, —C(═NOH)NR32R33, —C(═NOR36)R30, —C(═NNR32R33)R30, —C(═NNR34C(═O)R31)R30, —C(═NNR34C(═O)OR31)R30, —C(═S)NR32R33, —NC, —NO2, —NR32R33, —NR34NR32R33, —N═NR34, ═NR30, ═NOR30, —NR34OR36, —NR34C(═O)R30, —NR34C(═O)C(═O)R30, —NR34C(═O)OR31, —NR34C(═O)C(═O)OR31, —NR34C(═O)NR32R33, —NR34C(═O)NR34C(═O)R30, —NR34C(═O)NR34C(═O)OR30, —NR34C(═NR35)NR32R33, —NR34C(═O)C(═O)NR32R33, —NR34C(═S)R30, —NR34C(═S)OR30, —NR34C(═S)NR32R33, —NR34S(═O)2R31, —NR34S(═O)2NR32R33, —NR34P(═O)R38R38, —NR34P(═O)(NR32R33)(NR32R33), —NR34P(═O)(OR30)(OR30), —NR34P(═O)(SR30)(SR30), —OR30, ═O, —OCN, —OC(═O)R30, —OC(═O)NR32R33, —OC(═O)OR30, —OC(═NR35)NR32R33, —OS(═O)R30, —OS(═O)2R30, —OS(═O)2OR30, —OS(═O)2NR32R33, —OP(═O)R38R38, —OP(═O)(NR32R33)(NR32R33), —OP(═O)(OR30)(OR30), —OP(═O)(SR30)(SR30), —Si(R34)3, —SCN, ═S, —S(═O)6 R30, —S(═O)2OR30, —SO3R37, —S(═O)2NR32R33, —S(═O)NR32R33, —SP(═O)R38R38, —SP(═O)(NR32R33)(NR32R33), —SP(═O)(OR30)(OR30), —SP(═O)(SR30)(SR30), —P(═O)R38R38, —P(═O)(NR32R33)(NR32R33), —P(═O)(OR30)(OR30), and —P(═O)(SR30)(SR30); R20, R21, R24, R25, R26, R27, R30, R31, R34, R35, R36 and R37 at each occurrence is independently chosen from the group consisting of H, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C6-11aryl, C7-16arylalkyl, C3-11cycloalkyl, C4-17cycloalkylalkyl, 3-15 membered heterocycloalkyl, 4-21 membered heterocycloalkylalkyl, 5-15 membered heteroaryl, and 6-21 membered heteroarylalkyl wherein each of the foregoing groups (except for Hydrogen) may be optionally substituted by 1-10 R19; R28 at each occurrence is independently chosen from the group consisting of C1-10-alkyl, C2-10alkenyl, C2-6alkynyl, C6-11aryl, C7-16arylalkyl, C3-11cycloalkyl, C4-17-cycloalkylalkyl, 3-15 membered heterocycloalkyl, 4-21 membered heterocycloalkylalkyl, 5-15 membered heteroaryl, and 6-21 membered heteroarylalkyl wherein each of the foregoing groups may be optionally substituted by 1-10 R19; R22, R23, R32 and R33 at each occurrence is independently chosen from the group consisting of H, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C6-11aryl, C7-16arylalkyl, C3-11cycloalkyl, C4-17cycloalkylalkyl, 3-15 membered heterocycloalkyl, 4-21 membered heterocycloalkylalkyl, 5-15 membered heteroaryl, and 6-21 membered heteroarylalkyl wherein each of the foregoing groups (except for Hydrogen) may be optionally substituted by 1-10 R19;
or any R22 and R23 and/or R32 and R33 may form, together with the nitrogen atom to which they are attached, a 3-15 membered heterocycloalkyl optionally substituted by 1-10 R19 or a 5-15 membered heteroaryl optionally substituted by 1-10 R19; R38 at each occurrence is independently chosen from the group consisting of C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C6-11aryl, C7-16arylalkyl, C3-11cycloalkyl, C4-17cycloalkylalkyl, 3-15 membered heterocycloalkyl, 4-21 membered heterocycloalkylalkyl, 5-15 membered heteroaryl, and 6-21 membered heteroarylalkyl wherein each of the foregoing groups may be optionally substituted by 1-10 R19;
or any two R38 attached to the same phosphorus atom can, together with the phosphorus atom linking them, form a 3-10 membered heterocycloalkyl optionally substituted by 1-6 R19; R39 at each occurrence is independently chosen from the group consisting of C1-6alkyl optionally substituted by 1-13 halogen, C2-6alkenyl, C2-6alkynyl, C6-11aryl, C7-16arylalkyl, C3-11cycloalkyl, C4-17cycloalkylalkyl, 3-15 membered heterocycloalkyl, 4-21 membered heterocycloalkylalkyl, 5-15 membered heteroaryl, 6-21 membered heteroarylalkyl, halogen, —CN, —C(═O)R40, —C(═O)OR40, —C(═O)NR40R40, —C(═O)C(═O)R40, —C(═NR40)R40, —C(═NR40)NR40R40, —C(═NOH)NR40R40, —C(═NOR40)R40, —C(═NNR40R40R40, —C(═NNR40C(═O)R40)R40, —C(═NNR40C(═O)OR40)R40, —C(═S)NR40R40, —NC, —NO2, —NR40R40, —NR4NR40R40, —N═NR40, ═NR40, ═NOR40, —NR40OR40, —NR40C(═O)R40, —NR40C(═O)C(═O)R40, —NR40C(═O)OR40, —NR40C(═O)C(═O)OR40, —NR40C(═O)NR40R40, —NR40C(═O)NR40C(═O)R40, —NR40C(═O)NR40C(═O)OR40, —NR40C(═NR40)NR40R40, —NR40C(═O)C(═O)NR40R40, —NR40C(═S)R40, —NR40C(═S)OR40, —NR40C(═S)NR40R40, —NR40S(═O)2R40, —NR40S(═O)2NR40R40, —NR40P(═O)R41R41, —NR40P(═O)(NR40R40)(NR40R40), —NR40P(═O)(OR40)(OR40), —NR40P(═O)(SR40)(SR40), —OR40, ═O, —OCN, —OC(═O)R40, —OC(═O)NR40R40, —OC(═O)OR40, —OC(═NR40)NR40R40, —OS(═O)R40, —OS(═O)2R40, —OS(═O)2OR40, —OS(═O)2NR40R40, —OP(═O)R41R41, —OP(═O)(NR40R40)(NR40R40), —OP(═O)(OR40)(OR40), —OP(═O)(SR40)(SR40), —Si(R40)3, —SCN, ═S, —S(═O)nR40, —S(═O)2OR40, —SO3R40, —S(═O)2NR40R40, —S(═O)NR40R40, —SP(═O)R41R41, —SP(═O)(NR40R40)(NR40R40), —SP(═O)(OR40)(OR40), —SP(═O)(SR40)(SR40), —P(═O)R41R41, —P(═O)(NR40R40)(NR40R40), —P(═O)(OR40)(OR40), and —P(═O)(SR40)(SR40); R40 at each occurrence is independently chosen from the group consisting of H, C1-6alkyl, and C1-6-haloalkyl; R41 at each occurrence is independently chosen from the group consisting of C1-6alkyl and C1-6-haloalkyl; and n at each occurrence is independently selected from the group consisting of 0, 1, and 2. |
