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1. Compound of the formula (I) in which A represents CH2, CD2 or CH(CH3), R1 represents (C4-C6)-alkyl, (C3-C7)-cycloalkyl or phenyl,
where (C4-C6)-alkyl may be substituted up to six times by fluorine,where (C3-C7)-cycloalkyl may be substituted by 1 to 4 substituents independently of one another selected from the group consisting of fluorine, trifluoromethyl and (C1-C4)-alkyl,andwhere phenyl may be substituted by 1 to 4 substituents independently of one another selected from the group consisting of halogen, cyano, monofluoromethyl, difluoromethyl, trifluoromethyl, (C1-C4)-alkyl, (C3-C6)-cycloalkyl, (C1-C4)-alkoxy, difluoromethoxy and trifluoromethoxy, R2 represents hydrogen, (C1-C4)-alkyl, cyclopropyl, monofluoromethyl, difluoromethyl or trifluoromethyl, R3 represents a group of the formula where
* represents the point of attachment to the carbonyl group,L1A represents a bond or (C1-C4)-alkanediyl,
where (C1-C4)-alkanediyl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of fluorine, trifluoromethyl, (C1-C4)-alkyl, (C3-C7)-cycloalkyl, hydroxy and (C1-C4)-alkoxy,L1B represents a bond or (C1-C4)-alkanediyl,L1C represents a bond or (C1-C4)-alkanediyl,
where (C1-C4)-alkanediyl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of fluorine, trifluoromethyl, (C1-C4)-alkyl, (C3-C7)-cycloalkyl, hydroxy and (C1-C4)-alkoxy,R7 represents hydrogen, (C1-C6)-alkyl, (C2-C6)-alkenyl, (C2-C6)-alkynyl, (C3-C7)-cycloalkyl, cyano, 5- to 10-membered heteroaryl, naphthyl or phenyl,
where (C1-C6)-alkyl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of fluorine, trifluoromethyl, difluoromethoxy, trifluoromethoxy, hydroxy, (C1-C4)-alkoxy, (C1-C4)-alkoxycarbonyl, (C1-C4)-alkylsulphonyl, phenyl, phenoxy and benzyloxy,
where phenyl, phenoxy and benzyloxy for their part may be substituted by 1 to 3 halogen or (C1-C4)-alkoxy substituents,where (C3-C7)-cycloalkyl may be substituted by 1 or 2 substituents independently of one another selected from the group consisting of fluorine, trifluoromethyl, (C1-C4)-alkyl and (C1-C4)-alkoxy,andwhere phenyl and 5- to 10-membered heteroaryl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of halogen, cyano, nitro, difluoromethyl, trifluoromethyl, difluoromethoxy, trifluoromethoxy, —NH(CO)CH3, (C1-C4)-alkyl, (C1-C4)-cycloalkyl, (C1-C4)-alkenyl, (C1-C4)-alkylsulphonyl, (C1-C4)-alkoxycarbonyl and (C1-C4)-alkoxy,where (C1-C4)-alkoxy may be substituted by hydroxy,andin which 2 adjacent carbon atoms of the phenyl may be substituted by a difluoromethylenedioxy bridge,R8 represents hydrogen or (C1-C4)-alkyl,orR7 and R8 together with the carbon atom to which they are attached form a 3- to 7-membered carbocycle or a 4- to 7-membered heterocycle, where the 3- to 7-membered carbocycle and the 4- to 7-membered heterocycle for their part may be substituted by 1 or 2 substituents independently of one another selected from the group consisting of fluorine and (C1-C4)-alkyl,R9 represents hydrogen, cyano, (C1-C6)-alkyl, (C2-C6)-alkenyl, (C2-C6)-alkynyl, (C3-C7)-cycloalkyl, 5- to 10-membered heteroaryl or phenyl,
where (C1-C6)-alkyl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of fluorine, difluoromethyl, trifluoromethyl, difluoromethoxy, trifluoromethoxy, hydroxy, cyano, (C1-C4)-alkoxy, (C1-C4)-alkoxycarbonyl, (C1-C4)-alkylsulphonyl, 5- or 6-membered heteroaryl, phenyl, phenoxy and benzyloxy,
where phenyl, phenoxy and benzyloxy for their part may be substituted by 1 to 3 halogen or (C1-C4)-alkoxy substituents,where 5- or 6-membered heteroaryl may be benzo-fused or substituted by a 5- or 6-membered heteroaryl, where 5- or 6-membered heteroaryl may be substituted by (C1-C4)-alkyl or trifluoromethyl,where (C3-C7)-cycloalkyl may be substituted by 1 or 2 substituents independently of one another selected from the group consisting of fluorine, trifluoromethyl, (C1-C4)-alkyl and (C1-C4)-alkoxy,andwhere phenyl and 5- to 10-membered heteroaryl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of halogen, cyano, difluoromethyl, trifluoromethyl, difluoromethoxy, trifluoromethoxy, (C1-C4)-alkyl, (C1-C4)-cycloalkyl, (C1-C4)-alkoxy, (C1-C4)-alkoxycarbonyl and (C1-C4)-alkylsulphonyl,where (C1-C4)-alkoxy may be substituted by hydroxy,andwhere the phenyl may be substituted on two adjacent carbon atoms by a difluoromethylenedioxy bridge,R10 represents hydrogen or (C1-C4)-alkyl,orR9 and R10 together with the carbon atom to which they are attached form a 3- to 7-membered carbocycle or a 4- to 7-membered heterocycle,
where the 3- to 7-membered carbocycle and the 4- to 7-membered heterocycle for their part may be substituted by 1 or 2 substituents independently of one another selected from the group consisting of fluorine, benzyl and (C1-C4)-alkyl,with the proviso that the radicals R7 and R9 do not both simultaneously represent phenyl,orR7 and R9 together with the carbon atoms to which they are attached and the group L1B form a 3- to 7-membered carbocycle or a 4- to 7-membered heterocycle,
where the 3- to 7-membered carbocycle may be substituted by 1 or 2 substituents independently of one another selected from the group consisting of (C1-C4)-alkyl, fluorine, hydroxy and (C1-C4)-alkoxy,with the proviso that not more than one of the radical pairs R7 and R8, R9 and R10 and R7 and R9, respectively, simultaneously forms a carbo- or heterocycle,R11 represents hydrogen or (C1-C4)-alkyl,
where (C1-C4)-alkyl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of fluorine, trifluoromethyl, hydroxy and (C1-C4)-alkoxy,R12 represents hydrogen, (C1-C6)-alkyl, (C3-C7)-cycloalkyl, phenyl or benzyl,
where (C1-C6)-alkyl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of fluorine, trifluoromethyl, hydroxy, (C1-C4)-alkoxy and phenoxy,andwhere phenyl and benzyl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of halogen and trifluoromethyl,orR11 and R12 together with the nitrogen atom to which they are attached form a 4- to 7-membered azaheterocycle,
where the 4- to 7-membered azaheterocycle may be substituted by 1 or 2 substituents independently of one another selected from the group consisting of fluorine, trifluoromethyl, (C1-C4)-alkyl, (C3-C7)-cycloalkyl, hydroxy, (C1-C4)-alkoxy and 4- to 7-membered heterocyclyl,andL2 represents a bond or (C1-C4)-alkanediyl,R13 represents 5- to 9-membered azaheterocyclyl which is attached via a ring carbon atom,
where 5- to 9-membered azaheterocyclyl may be substituted by 1 to 5 substituents independently of one another selected from the group consisting of fluorine, trifluoromethyl, (C1-C4)-alkyl, (C3-C7)-cycloalkyl and benzyl,andwhere 5- to 9-membered azaheterocyclyl may be fused to a phenyl ring which for its part may be substituted by 1 or 2 substituents selected from the group consisting of halogen, (C1-C4)-alkyl, (C1-C4)-alkoxy and trifluoromethyl,orrepresents adamantyl, R4 represents hydrogen, R5 represents hydrogen, halogen, cyano, monofluoromethyl, difluoromethyl, trifluoromethyl, (C1-C4)-alkyl, (C3-C7)-cycloalkyl, (C2-C4)-alkenyl, (C2-C4)-alkynyl, difluoromethoxy, trifluoromethoxy, (C1-C4)-alkoxy, amino, 4- to 7-membered heterocyclyl or 5- or 6-membered heteroaryl, R6 represents hydrogen, cyano or halogen, and its N-oxides, salts, solvates, salts of the N-oxides and solvates of the N-oxides and salts. |
