System And Method For Functional Brain Organization Mapping

摘要

Systems and method for producing functional brain organization maps are provided. The method includes providing functional connectivity magnetic resonance image (fcMRI) data, a population atlas, a variation map indicative of inter-subject variability in the atlas. The method also includes initializing a subject map using the atlas, determining a reference signal for each functional connectivity network in the subject map using signals derived from the fcMRI data, computing correlations between the signals and reference signal of each functional connectivity network, and iteratively updating the subject map by reassigning locations in the subject brain when correlating with a functional connectivity network, updating at each iteration the reference signal using the subject map, the population atlas, the variation map, and the set of fcMRI data. The method further includes generating a report indicative of a functional brain organization for the brain of the subject using the subject map.

主权项

1. A method for producing a functional brain map of a subject, the method comprising:
i. providing a set of time-series functional magnetic resonance image (fMRI) data acquired from a subject; ii. providing a population atlas that associates locations in a population brain to a plurality of functional connectivity networks, the population brain representing a population of subjects; iii. providing a variation map indicative of inter-subject variability in the population atlas; iv. initializing a subject map using the population atlas, the subject map defining a plurality of functional connectivity networks and indicating locations in a brain of the subject that are assigned to the plurality of functional connectivity networks; v. determining a reference signal for each functional connectivity network in the subject map using time-series signals derived from the set of time-series fMRI data; vi. computing a plurality of correlation values between the time-series signals derived from the set of time-series fMRI data and each reference signal determined in step (v); vii. updating the subject map by reassigning locations in the subject brain based on the computed correlation values; viii. updating the reference signal for each functional connectivity network using the updated subject map, the population atlas, the variation map, and the set of fMRI data; ix. iteratively repeating steps (vi), (vii) and (viii) until a stopping criterion is satisfied; and x. generating a report indicative of a functional brain organization for the brain of the subject using the subject map.