发明名称 |
CONTAMINANT REMOVAL METHOD |
摘要 |
A method for purifying Apo A-l is provided including the steps of providing a solution comprising Apo A-l and guanidine hydrochloride and filtering the solution through a filter having a pore size in a range from 15 nrn to 35 nm to thereby reduce viral contamination of the Apo A-l. An Apo A-f preparation is provided having at least a 12 log LRV (log reduction value) for a parvovirus; and/or at least 9 log LRV for a non-enveloped virus; and/or at least 8.5 log LRV for a lipid enveloped virus. Also provided are pharmaceutical compositions and reconstituted high density lipoprotein formulation comprising Apo A-l and methods of treating diseases disorders or conditions. |
申请公布号 |
WO2015017888(A8) |
申请公布日期 |
2015.10.01 |
申请号 |
WO2014AU00790 |
申请日期 |
2014.08.08 |
申请人 |
CSL LIMITED |
发明人 |
WARREN, GARY;VUCICA, YVONNE;KEMPF, CHRISTOPH;STUCKI, MARTIN |
分类号 |
C07K14/775;A61K38/16;C07K1/34;C07K1/36 |
主分类号 |
C07K14/775 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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