发明名称 |
ENHANCEMENT OF RECOMBINANT PROTEIN EXPRESSION WITH COPPER |
摘要 |
The present invention provides a novel use of copper (cupric ion) for improved cell expression of recombinant proteins, particularly coagulation proteins such as recombinant Factor VIII, B Domain Deleted recombinant Factor VIII, recombinant Factor IX and rFVII or rFVIIa. The use of such cell culture supplement results in higher productivity and robustness of the manufacturing process. This invention results in improvements in cell expression and product stability. |
申请公布号 |
WO2015143512(A2) |
申请公布日期 |
2015.10.01 |
申请号 |
WO2015BR00025 |
申请日期 |
2015.03.03 |
申请人 |
ADVANTECH BIOSCIENCE FARMACÊUTICA LTDA. |
发明人 |
SADETTIN, SEYIT OZTURK;MATTHEW, VERON CAPLE |
分类号 |
C12P21/02;C12N5/02 |
主分类号 |
C12P21/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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