发明名称 |
DEVICE FOR DETECTING A DYNAMICAL NETWORK BIOMARKER, METHOD FOR DETECTING SAME, AND PROGRAM FOR DETECTING SAME |
摘要 |
The present invention provides a device, method, and program for detection of a biomarker candidate that may be used in a diagnosis of a pre-disease state indicating a transition from a healthy state to a disease state. Biological samples are collected from a subject to be measured at different times. Statistical data is obtained by aggregating measurement data obtained in measurement on collected biological samples. Thereafter, a process of obtaining high-throughput data (s1), a process of choosing differential biological molecules (s2), a process of clustering (s3), a process of choosing a DNB candidate (s4), and a process of identifying a DNB by significance analysis (s5) are carried out. |
申请公布号 |
US2015278433(A1) |
申请公布日期 |
2015.10.01 |
申请号 |
US201314430724 |
申请日期 |
2013.02.12 |
申请人 |
AIHARA Kazuyuki;CHEN Luonan;LIU Rui;LIU Zhiping;LI Meiyi;Japan Science and Technology Agency |
发明人 |
Aihara Kazuyuki;Chen Luonan;Liu Rui;Liu Zhiping;Li Meiyi |
分类号 |
G06F19/18;G06F19/22 |
主分类号 |
G06F19/18 |
代理机构 |
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代理人 |
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主权项 |
1. A device for detecting a candidate for a biomarker based on measurement data on a plurality of factors obtained in measurement on a biological object to be measured, the biomarker being an index of a symptom of the biological object, said device comprising:
classification means for classifying factors into clusters based on a correlation of time-dependent changes of measurement data for each factor; choosing means for choosing one of the clusters that satisfies choice conditions that are predetermined based on a correlation of time-dependent changes of measurement data for each factor and time-dependent changes of measurement data among different factors; and detection means for detecting a factor in the chosen cluster as a candidate for a biomarker. |
地址 |
Tokyo JP |