SHORT-WAVELENGTH INFRARED (SWIR) FLUORESCENCE IN VIVO AND INTRAVITAL IMAGING WITH SEMICONDUCTOR NANOCRYSTALS

摘要

InAs based core-shell particles which leads to tunable, narrow emitting semiconductor nanocrystals with a very high quantum yield which can be preserved in physiological buffers with long stability can used for short wavelength infrared (SWIR) imaging. Increased resolution with reduced read time and increased imaging frequency can provide advantages in in vivo applications.

主权项

1. A method of imaging comprising:
introducing a composition including a particle containing a semiconductor nanocrystal into a subject; exciting the particle with an excitation light source; detecting emission from the particle in short wavelength infrared (SWIR) spectrum; and generating a real-time image of an area surrounding of the subject from the detected SWIR emission.