| 摘要 |
<p>The present invention relates to the use of Rspondins, particularly Rspon din2 (Rspo2) or Rspondin3 (Rspo3) or Rspondin nucleic acids, or regulators o r effectors or modulators of Rspondin e.g. Rspo2 and/or Rspo3 to promote or inhibit angiogenesis and/or vasculogenesis, respectively. The invention is b ased on the demonstration that Rspo3 and Rspo2 are angiogenesis promoters, a nd the identification of Rspo2 and 3 as positive regulators of vascular endo thelial growth factor (VEGF). These results indicate a major role for Rspond ins, particularly Rspo3 and/or Rspo2 in the signalling system during angioge nesis. The invention also relates to the use regulators or effectors or modu lators of Rspondin3, including agonists and antagonists, in the treatment of conditions where treatment involves inhibiting or promoting angiogenesis an d/or vasculogenesis.</p> |
