发明名称 |
PROCESS FOR PRODUCING 1-BENZYL-4-[(5,6-DIMETHOXY-1-INDANONE)-2-YLIDENE]METHYLPIPERIDINE |
摘要 |
It is intended to provide a process for producing 1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-ylidene]methylpiperidine represented by the structural formula (I): (I) which is useful as an intermediate material for a pharmaceutical or a solvate thereof in which impurity content is further reduced and operation is simple and suitable for industrial production by reacting 5,6-dimethoxy-1-indanone with 1-benzyl-4-formylpiperidine in a reaction solvent in the presence of a base and then gradually crystallizing a target substance in a reaction mixture in a high temperature region.
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申请公布号 |
EP1911745(A1) |
申请公布日期 |
2008.04.16 |
申请号 |
EP20060768369 |
申请日期 |
2006.07.24 |
申请人 |
EISAI R&D MANAGEMENT CO., LTD. |
发明人 |
IMAI, AKIO;SHIMOTANI, AKIHIKO;TSURUGI, TOMIO;NARABE, YUKIO |
分类号 |
C07D211/32 |
主分类号 |
C07D211/32 |
代理机构 |
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代理人 |
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主权项 |
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