SUBUNIT VACCINE AGAINST WEST NILE VIRAL INFECTION

摘要

An immunogenic composition is described that preferably contains a recombinantly produced form of truncated West Nile envelope glycoprotein and one or more adjuvants acceptable for use in the general population, including immunosuppressed, immunocompromised, and immunosenescent populations. The disclosed immunogenic compositions can further comprise a recombinantly produced non-structural (non-envelope) West Nile protein. An adjuvant typically comprises a saponin, saponin-based adjuvant (e.g., ISCOMATRIX® or GPI-0100), emulsion-based adjuvant (e.g., Co-Vaccine HT), or alum-based adjuvant. A pharmaceutically acceptable vehicle may also be included in the immunogenic composition.