摘要 |
<p>The present invention provides a composition comprising nilvadipine, or a salt, derivative, prodrug, or polymorph thereof, useful in the treatment and prevention of hypertension or related cardiovascular disorders. In one embodiment, the composition comprises nanoparticulate particles comprising nilvadipine, or a salt, derivative, prodrug, or polymorph thereof, and at least one surface stabilizer. The nanoparticulate particles have an effective average particle size of less than about 2000 nm. In another embodiment, the composition comprises a modified release composition that, upon administration to a patient, delivers nilvadipine, or a salt, derivative, prodrug, or polymorph thereof, in a bimodal, multimodal or continuous manner. The invention also relates to dosage forms containing such compositions, and to methods for the treatment and prevention of hypertension or related cardiovascular disorders.</p> |
申请人 |
ELAN PHARMA INTERNATIONAL LIMITED;DEVANE, JOHN;STARK, PAUL;FANNING, NIALL;REKHI, GURVINDER;JENKINS, SCOTT;LIVERSIDGE, GARY |
发明人 |
DEVANE, JOHN;STARK, PAUL;FANNING, NIALL;REKHI, GURVINDER;JENKINS, SCOTT;LIVERSIDGE, GARY |