DERIVATIZATION AND LOW LEVEL DETECTION OF DRUGS IN BIOLOGICAL FLUID AND OTHER SOLUTION MATRICES USING A PROXY MARKER
摘要
<p>New and improved mass spectrometry methods of determining the pharmacokinetic fate of a compound of interest are described. The methods involve PEGylating the compound, administering to a biological system, withdrawing an analyte from said system, and subjecting said analyte to in-source ionization and fragmentation into PEG ions that are then measured as a surrogate marker or markers for the presence and/or amount of said compound in said analyte.</p>
