PYRAZOLE-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES FOR USE IN THE TREATMENT OF CANCER AND AUTOIMMUNE DISORDERS

摘要

Compounds of formula (I) are inhibitors of PDK1 and CHK1 activity, and of use in the treatment of cancer and autoimmune disorders (I) : wherein R<SUB>2</SUB> is a radical of formula R<SUB>7</SUB>-(CH<SUB>2</SUB>)<SUB>n-</SUB>, or a radical of formula -Alk-N(-R<SUB>8</SUB>)-R<SUB>9</SUB> wherein n is 0, 1 , 2 or 3 and AIk is C<SUB>1</SUB>-C<SUB>6</SUB> alkylene; R<SUB>7</SUB> is (i) a heterocyclic ring of 5 or 6 ring atoms coupled via a ring carbon wherein the sole heteroatom is nitrogen, optionally substituted by C<SUB>1</SUB>-C<SUB>6</SUB> alkyl or aryl C<SUB>1</SUB>-C<SUB>6</SUB> alkyl, (ii) 1-aza-bicyclo[2.2.2] oct-3-yl, or (iii) 8-methyl-8-aza-bicyclo[3.2.1] oct-3-yl; R<SUB>8</SUB> and R<SUB>9</SUB> are independently selected from hydrogen or C<SUB>1</SUB>-C<SUB>3</SUB> alkyl; and the remaining substituents are as defined in the claims.