PROSTATE CANCER THERAPEUTICS AND DIAGNOSTICS BASED ON CONFORMERS OF PROSTATIC ACID PHOSPHATASE

摘要

The signals that determine important characteristics of prostate cancer, such as loss of dependence on androgens are described. A key protein, prostatic acid phosphatase, is shown to fold in different ways in response to cellular signals, and the conformer "mix" of this protein in prostatic cells may represent a fundamental difference between normal cells and cancer cells.