| 摘要 |
<p>Peptide (I) that contains an epitope consisting of sequences (SEQ ID NOs: 1-3) and is not longer than 24 amino acids is new. Peptide (I) that contains an epitope consisting of sequences (SEQ ID NOs: 1-3) and is not longer than 24 amino acids is new. Tyr-Lys-Thr-Leu-Arg-Ala-Glu-Gln-Ala-Ser-Gln-Glu-Val-Lys-Asn-Trp-Met-Thr-Glu-Thr (SEQ ID NO: 1) Leu-Leu-Val-Gln-Asn-Ala-Asn-Pro-Asp-Cys-Lys-Thr-Ile-Leu-Lys-Ala-Leu-Gly-Pro-Ala (SEQ ID NO: 2) SEQ ID NOs: 1-3Lys-Thr-Ile-Leu-Lys-Ala-Leu-Gly-Pro-Ala-Ala-Thr-Leu-Glu-Glu-Met-Met-Thr-Ala-Cys (SEQ ID NO: 3). Independent claims are also included for the following: (1) multiepitope peptide (Ia) that includes at least one of (SEQ ID NOs: 1-3); (2) (I) where associated with a biotinylated complex consisting of the a and b-chains (DRa, b) of a HLA (= human leucocyte antigen), a spacer arm and streptavidin to form a class II tetramer; (3) nucleic acid (NA) that encodes at least one (I) or (Ia); (4) expression vector that contains NA; (5) antibody (Ab) that binds specifically to (SEQ ID NOs: 1-3); (6) isolated antigen-presenting cell (APC) associated with at least one (I), NA and/or vector of (4); (7) isolated clone of T helper cells comprising a receptor specific for a complex of HLA-DR1 and (I); (8) diagnostic methods for determining the immune status of a subject susceptible to HIV infection; and (9) diagnostic kit containing at least one (I) or the tetramer of (2). ACTIVITY : Anti-HIV. No details of tests for anti-HIV activity are given. MECHANISM OF ACTION : Vaccine; (I) bind to HLA-DR1 to induce an immune response, dependent on CD4+ T cells, against HIV antigens.</p> |
