DERIVATE VON TRIAZOLYL-IMIDAZOPYRIDINE UND VON TRIAZOLYLPURINE ALS LIGANDE DES ADENOSINE A2A REZEPTOREN UND IHRE VERWENDUNG ALS MEDICAMENTE

摘要

Compounds of formula (I) wherein: X is N; R₁ is C₁-C₆ linear or branched alkyl or C₁-C₆ linear or branched alkenyl; R₂ is hydrogen, C₁-C₆ linear or branched alkyl or C₁-C₆ linear or branched alkenyl, C₆-C₁₄ aryl or C₆-C₁₄ aryl(C₁-C₆) linear or branched alkyl or C₆-C₁₄ aryl(C₁-C₆) linear or branched alkenyl, with the aryl group optionally substituted by one or more substituents, either the same or different, selected from the group consisting of halogen, hydroxy, C₁-C₆ alkoxy linear or branched or C₁14 C₆ alkenyloxy linear or branched, amino, optionally mono- or disubstituted with C₁-C₆ linear or branched alkyl; R₃ is NH₂, NHR₄; R₄ is C₁-C₆ alkyl or C₁-C₆ hydroxyalkyl, C₁-C₃ alkoxyalkyl, amino(C₁-C₆)alkyl, where the amino group is optionally substituted with one or two C₁-C₃ linear or branched alkyl groups, or with one or two C₂-C₃ alkenyl groups C₆-C₁₄ aryl or C₆-C₁₄ aryl(C₁-C₆)alkyl, with the aryl group optionally substituted by one or more substituents, either the same or different, selected from the group consisting by halogen, hydroxy, C₁-C₆ alkoxy linear or branched or C₁-C₆ alkenyloxy linear or branched, amino, mono- or di-substituted with C₁-C₆ alkyl linear or branched or C₁-C₆ alkenyl linear or branched; and their pharmaceutically acceptable salts. These compounds are antagonists of the adenosine A_2a receptor and useful as medicaments, in particular for the treatment of Parkinson's disease.