SKIN CELL BIOMARKERS AND METHODS FOR IDENTIFYING BIOMARKERS USING NUCLEIC ACID MICROARRAYS

摘要

The present invention provides biomarker genes of mammalian skin-derived cells. A plurality of differentially-expressed up-regulated (signature) and down-regulated (anti-signature) biomarker genes for human keratinocytes, melanocytes, and fibroblasts are identified. Biomarker genes for cells at abnormal states such as melanoma cells are also provided. Further, there are provided analytical bioinformatic methods for identifying biomarker genes based on nucleic acid microarray data.