PROSTAGLANDIN B1, MACROMOLECULES AS ANTI-INFLAMMATORY AGENTS

摘要

This invention describes novel uses for macromolecular derivatives of a fatty acid such as prostaglandin B1, which include polymers, and oligomeric compounds thereof such as dimers, trimers and tetramers of the same. When used for therapeutic purposes in vivo and in vitro, such macromolecules have been discovered to be anti-inflammatory and anti-oxidant in effect. The class of macromolecules, as described above, are generically referred to as PGBx. They are discovered to be excellent membrane stabilizers and cytoprotective agents. They act to protect cells by increasing the resistance of each cell against injury from phospholipases and free radical induced oxidations, particularly the mediation of phospholipase A2 enzymes. PGBx is differentiated over the prior art in at least that characteristic which makes it an effective dual agent acting as both an anti-phospholipase enzyme inhibitor and an anti-oxidant.