发明名称 |
Use of nucleic acids containing unmethylated CpG dinucleotide in combination with alum as adjuvants |
摘要 |
<p>The present invention is based on the finding that nucleic acids containing at least one unmethylated cytosine-guanine (CpG) dinucleotide affect immune responses in a subject. These nucleic acids containing at least one unmethylated cytosine-guanine (CpG) dinucleotide can be used to induce an immune response in a subject. The method includes administering to the subject a therapeutically effective amount of nucleic acid encoding an antigenic polypeptide, and a therapeutically effective amount of an oligonucleotide containing at least one unmethylated CpG dinucleotide. The invention also provides a method for treating a subject having or at risk of having viral-mediated disorder, comprising administering to the subject a therapeutically effective amount of a nucleic acid encoding an antigenic polypeptide and an effective amount of an oligonucleotide containing at least one unmethylated CpG dinucleotide</p> |
申请公布号 |
EP1005368(B1) |
申请公布日期 |
2009.09.02 |
申请号 |
EP19980912919 |
申请日期 |
1998.03.10 |
申请人 |
OTTAWA HOSPITAL RESEARCH INSTITUTE;COLEY PHARMACEUTICAL GMBH;UNIVERSITY OF IOWA RESEARCH FOUNDATION;THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY DEPARTMENT OF HEALTH AND HUMAN SERVICES |
发明人 |
DAVIS, HEATHER, L.;SCHORR, JOACHIM;KRIEG, ARTHUR, M.;KLINMAN, DENNIS |
分类号 |
A61K39/39;A61K47/02;A61K39/29;A61K48/00;A61P31/04;A61P31/12;A61P33/00 |
主分类号 |
A61K39/39 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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