COMPOSITION FOR PREVENTING OR TREATING A DISEASE MEDIATED BY OVEREXPRESSION OF HEAT SHOCK PROTEIN 27

摘要

A composition for preventing and treating diseases mediated by the overexpression of heat shock protein 27 (HSP 27), which contains Limonium tetragonum or active compound isolated from the Limonium tetragonum is provided to prevent or treat cancer, Alzheimer disease, Parkinson's disease, and Huntington disease without side effect. A composition for preventing and treating diseases mediated by the overexpression of HSP 27 comprises a Limonium tetragonum as an active ingredient. The Limonium tetragonum is pulverized product of the row material, dried product of the row material or crude extract of C1-C4 alcohol solvent. The composition comprises a compound of the chemical formula 1 or pharmaceutically allowable salt as active ingredient. The compound of the chemical formula 1 is plumbagin and isolated from the Limonium tetragonum. A method for isolating a plumbagin from the Limonium tetragonum comprises: a step of extracting the Limonium tetragonum with C1-C4 alcohol solvent to obtain crude extract; a step of sequenciaaly extracting with hexane, ethylacetate, and chloroform to obtain chloroform soluble fraction; and a step of performing chromatography to purify.