METHODS FOR DIFFERENTIAL DIAGNOSIS OF MELANOCYTIC LESIONS

摘要

The invention provides a method for determining whether a melanocytic lesion in a patient is malignant which comprises determining a quantity of gp100 present within a nuclear compartment in stained cells in a tissue sample from the melanocytic lesion; determining a quantity of gp100 present within a non-nuclear compartment in the stained cells in such tissue sample; obtaining a ratio of the quantity of gp100 present within the nuclear compartment relative to the quantity of gp100 present within the non-nuclear compartment; and comparing the ratio so obtained with a predetermined ratio associated with a melanocytic lesion that is malignant; wherein the melanocytic lesion is determined to be malignant if the ratio obtained is less than the predetermined ratio.