| 发明名称 |
STABLE AQUEOUS SOLUTION OF GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR |
| 摘要 |
PROBLEM TO BE SOLVED: To provide a composition containing GS-CSF and a method for stabilizing the GS-CSF so that an chelating agent does not modify an N terminal. SOLUTION: The recombination type granulocyte macrophage colony stimulating factor is sargramostim. An aqueous solution containing EDTA of 0.05 mM to 50 mM and having a pH of 7.4 is added with TRIS-HCL of 10 mM, mannitol of 40 mg/ml and saccharose of 10 mg/ml. COPYRIGHT: (C)2009,JPO&INPIT
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| 申请公布号 |
JP2009161538(A) |
申请公布日期 |
2009.07.23 |
| 申请号 |
JP20090014633 |
申请日期 |
2009.01.26 |
| 申请人 |
BAYER SCHERING PHARMA AG |
发明人 |
PETTIT DEAN K;JOCHHEIM CLAUDIA M |
| 分类号 |
A61K9/08;A61K38/00;A61K9/19;A61K36/06;A61K38/19;A61K47/10;A61K47/18;A61K47/26;A61P1/00;A61P7/06;A61P31/04;A61P35/00;A61P35/02;A61P37/04;C07K14/535 |
主分类号 |
A61K9/08 |
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