COMPOUNDS EXHIBITING GLUCAGON ANTAGONIST AND GLP-1 AGONIST ACTIVITY
摘要
Glucagon analogs are disclosed that exhibit both glucagon antagonist and GLP-1 agonist activity. In one embodiment, the glucagon antagonist/GLP-1 agonist comprises a modified amino acid sequence of native glucagon, in which the first one to five N-terminal amino acids of native glucagon is deleted and in which the alpha helix is stabilized.
申请公布号
WO2009058734(A4)
申请公布日期
2009.07.23
申请号
WO2008US81333
申请日期
2008.10.27
申请人
INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION;DIMARCHI, RICHARD, D.;YANG, BIN;OUYANG, CHENGUANG