发明名称 |
COMBINED THERAPY AGAINST TUMORS COMPRISING SUBSTITUTED ACRYLOYL DISTAMYCIN DERIVATIVES AND ALKYLATING AGENTS |
摘要 |
Compounds which are alpha-halogenoacryloyl distamycin derivatives of formula (I) wherein R1 is a bromine or chlorine atom; R2 is a distamycin or distamycin-like framework as set forth in the specification; or a pharmaceutically acceptable salt thereof; are cytotoxic agents particularly effective in the treatment of tumors over expressing GSH/GSTs system and which are poorly responsive or even resistant to conventional antitumor therapies. |
申请公布号 |
PL202053(B1) |
申请公布日期 |
2009.05.29 |
申请号 |
PL20010365158 |
申请日期 |
2001.06.20 |
申请人 |
NERVIANO MEDICAL SCIENCES S.R.L. |
发明人 |
GERONI MARIA CRISTINA ROSA;COZZI PAOLO;BERIA ITALO |
分类号 |
A61K31/409;C07D403/14;A61K31/282;A61K31/4025;A61K31/4155;A61K31/4178;A61K33/24;A61K45/00;A61K45/06;A61P35/00;A61P43/00;C07D207/34 |
主分类号 |
A61K31/409 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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