| 摘要 |
<p>The present invention relates to an improved process for the preparation of Tadalafil intermediate (1R,3R)Methyl-1,2,3,4-tetrahydro-1-(3,4-methylenedioxyphenyl)-9H-pyrido[3,4-b]indole-3-carboxylate of formula III comprising a modified Pictet-Spengler reaction between the compound of formula II and piperonal in a mixture of aromatic hydrocarbon solvent and a glycol.</p> |
| 申请人 |
ORCHID CHEMICALS & PHARMACEUTICALS LIMITED;VEERAPPAN, VIJAYABASKAR;SWAMINATHAN, SUSI;MAHENDER, RAO, SIRIPRAGADA |
发明人 |
VEERAPPAN, VIJAYABASKAR;SWAMINATHAN, SUSI;MAHENDER, RAO, SIRIPRAGADA |
