METHODS AND COMPOSITIONS FOR THE SITE-SELECTIVE INCORPORATION OF FLUORINATED AMINO ACIDS INTO POLYPEPTIDES
摘要
Compositions including orthogonal aminoacyl-tRNA synthetases (O-RS) that preferentially aminoacylate an orthogonal tRNA (O-tRNA) with trifluoromethoxyphenylalanine are provided. Nucleic acids encoding these aminoacyl-tRNA synthetases are also provided.
申请公布号
WO2009049223(A2)
申请公布日期
2009.04.16
申请号
WO2008US79603
申请日期
2008.10.10
申请人
IRM LLC;THE SCRIPPS RESEARCH INSTITUTE;CELLITTI, SUSAN, E;JONES, DAVID, H;RYU, YOUNGHA;SCHULTZ, PETER, G.;GEIERSTANGER, BERNHARD, H.
发明人
CELLITTI, SUSAN, E;JONES, DAVID, H;RYU, YOUNGHA;SCHULTZ, PETER, G.;GEIERSTANGER, BERNHARD, H.
