发明名称 |
ANTIBODY SPECIFIC TO INTACT HUMAN AUTOTAXIN, METHOD OF SCREENING THE SAME AND METHOD AND REAGENT FOR EXAMINING MALIGNANT LYMPHOMA BY ASSAYING AUTOTAXIN |
摘要 |
<p>A screening method is provided for antibody specifically recognizing naturally-occurring form of human autotaxin in a state in which it is present in the body without being denatured, comprising the steps of: binding a binding factor capable of capturing a candidate antibody of the antibody to a solid phase; binding the candidate antibody of the antibody to the binding factor; allowing naturally-occurring form of human autotaxin to react on a system in which the candidate antibody has reacted; and selecting an antibody that specifically recognizes the naturally-occurring form of human autotaxin by using as an indicator thereof the binding strength of the naturally-occurring form of human autotaxin to the antibody. Moreover, a detecting method for malignant lymphoma is provided comprising: measuring the concentration of autotaxin in a human specimen, and judging to be a malignant lymphoma in the case that value exhibits a significantly higher value than normal values comprised of measured values from normal healthy subjects.</p> |
申请公布号 |
EP2048501(A1) |
申请公布日期 |
2009.04.15 |
申请号 |
EP20070792235 |
申请日期 |
2007.08.02 |
申请人 |
THE UNIVERSITY OF TOKYO;TOSOH CORPORATION |
发明人 |
AOKI, JUNKEN;ARAI, HIROYUKI;YATOMI, YUTAKA;IKEDA, HITOSHI;NAKAMURA, KAZUHIRO;IGARASHI, KOJI;IDE, KAZUFUMI |
分类号 |
G01N33/53;C07K16/18;C07K16/28;C07K16/40;G01N33/564;G01N33/573 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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